Disease of Blood ICD 10 Codes (D50-D89)

“Diseases of the blood and blood-forming organs and certain disorders” is a broad medical category (D50-D89) encompassing a range of conditions that affect the blood and its components and disorders related to the organs responsible for blood production and regulation. This category includes various hematological disorders and conditions, such as:

  1. Anemia is characterized by a decrease in the number of red blood cells or a decrease in the amount of hemoglobin in the blood. It can result from various causes, including iron deficiency, vitamin deficiencies, chronic diseases, or genetic factors.
  2. Hemophilia: Hemophilia is a genetic disorder that impairs the blood’s ability to clot properly, leading to prolonged bleeding and easy bruising.
  3. Leukemia: Leukemia is a type of cancer that affects the bone marrow and blood, causing an abnormal increase in white blood cells. There are different types of leukemia, including acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic myeloid leukemia (CML).
  4. Thrombocytopenia: Thrombocytopenia is a condition characterized by a low platelet count in the blood, which can lead to an increased risk of bleeding and bruising.
  5. Sickle Cell Disease: Sickle cell disease is a genetic disorder that affects the shape of red blood cells, causing them to become rigid and assume a “sickle” shape. This can lead to pain, anemia, and other complications.
  6. Polycythemia: Polycythemia is a condition in which there is an excessive production of red blood cells, leading to an increased blood volume and viscosity.
  7. Myelodysplastic Syndromes (MDS) refers to bone marrow disorders characterized by abnormal blood cell production. It can progress to acute leukemia in some cases.
  8. Hemochromatosis: Hemochromatosis is a genetic disorder that causes the body to absorb and store too much iron, which can lead to organ damage over time.
  9. Idiopathic Thrombocytopenic Purpura (ITP): ITP is an autoimmune disorder in which the immune system mistakenly destroys platelets, leading to a low platelet count and an increased risk of bleeding.
  10. Coagulation disorders affect the blood’s ability to clot properly and can lead to bleeding disorders (hemorrhagic) or clotting disorders (thrombotic), such as von Willebrand disease or deep vein thrombosis.
  11. Bone Marrow Disorders: Various conditions can affect the bone marrow, where blood cells are produced, including aplastic anemia, myelofibrosis, and others.

These are just a few examples of the many diseases and disorders that fall under the “Diseases of the blood and blood-forming organs and certain disorders.” Each condition has its causes, symptoms, diagnostic methods, and treatment approaches, and they are typically managed by hematologists medical specialists who focus on blood-related disorders.

D50-D53 Nutritional Anemias:

These codes represent a group of anemias that result from various nutritional deficiencies. The most common forms include:

  • D50 Iron-deficiency anemia: Often caused by a lack of dietary iron or poor absorption of iron by the body. It results in a reduced ability of the blood to carry oxygen.
  • D51 Vitamin B12-deficiency anemia: Typically caused by inadequate intake or absorption of vitamin B12, which is essential for red blood cell production.
  • D52 Folate-deficiency anemia: Results from insufficient dietary intake or absorption of folate (vitamin B9), which is necessary for proper red blood cell formation.
  • D53 Other nutritional anemias: Encompasses anemias arising from various nutritional deficiencies other than iron, vitamin B12, or folate.
ICD10 CodesDescription
D50.0Iron deficiency anemia secondary to blood loss (chronic)
D50.1Sideropenic dysphagia
D50.8Other iron deficiency anemias
D50.9Iron deficiency anemia, unspecified
D51.0Vitamin B12 deficiency anemia due to intrinsic factor deficiency
D51.1Vitamin B12 deficiency anemia due to selective vitamin B12 malabsorption with proteinuria
D51.2Transcobalamin II deficiency
D51.3Other dietary vitamin B12 deficiency anemia
D51.8Other vitamin B12 deficiency anemias
D51.9Vitamin B12 deficiency anemia, unspecified
D52.0Dietary folate deficiency anemia
D52.1Drug-induced folate deficiency anemia
D52.8Other folate deficiency anemias
D52.9Folate deficiency anemia, unspecified
D53.0Protein deficiency anemia
D53.1Other megaloblastic anemias, not elsewhere classified
D53.2Scorbutic anemia
D53.8Other specified nutritional anemias
D53.9Nutritional anemia, unspecified

D55-D59 -Hemolytic Anemias:

These codes cover a group of anemias characterized by the destruction of red blood cells (hemolysis) either within the bloodstream or in the spleen. Hemolytic anemias can be inherited (e.g., sickle cell anemia) or acquired (e.g., autoimmune hemolytic anemia).

ICD 10 CodesDescription
D550Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
D551Anemia due to other disorders of glutathione metabolism
D552Anemia due to disorders of glycolytic enzymes
D5521Anemia due to pyruvate kinase deficiency
D5529Anemia due to other disorders of glycolytic enzymes
D553Anemia due to disorders of nucleotide metabolism
D558Other anemias due to enzyme disorders
D559Anemia due to enzyme disorder, unspecified
D560Alpha thalassemia
D561Beta thalassemia
D562Delta-beta thalassemia
D563Thalassemia minor
D564Hereditary persistence of fetal hemoglobin [HPFH]
D565Hemoglobin E-beta thalassemia
D568Other thalassemias
D569Thalassemia, unspecified
D5700Hb-SS disease with crisis, unspecified
D5701Hb-SS disease with acute chest syndrome
D5702Hb-SS disease with splenic sequestration
D5703Hb-SS disease with cerebral vascular involvement
D5709Hb-SS disease with crisis with other specified complication
D571Sickle-cell disease without crisis
D5720Sickle-cell/Hb-C disease without crisis
D57211Sickle-cell/Hb-C disease with acute chest syndrome
D57212Sickle-cell/Hb-C disease with splenic sequestration
D57213Sickle-cell/Hb-C disease with cerebral vascular involvement
D57218Sickle-cell/Hb-C disease with crisis with other specified complication
D57219Sickle-cell/Hb-C disease with crisis, unspecified
D573Sickle-cell trait
D5740Sickle-cell thalassemia without crisis
D5741Sickle-cell thalassemia, unspecified, with crisis
D57411Sickle-cell thalassemia, unspecified, with acute chest syndrome
D57412Sickle-cell thalassemia, unspecified, with splenic sequestration
D57413Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
D57418Sickle-cell thalassemia, unspecified, with crisis with other specified complication
D57419Sickle-cell thalassemia, unspecified, with crisis
D5742Sickle-cell thalassemia beta zero without crisis
D57431Sickle-cell thalassemia beta zero with acute chest syndrome
D57432Sickle-cell thalassemia beta zero with splenic sequestration
D57433Sickle-cell thalassemia beta zero with cerebral vascular involvement
D57438Sickle-cell thalassemia beta zero with crisis with other specified complication
D57439Sickle-cell thalassemia beta zero with crisis, unspecified
D5744Sickle-cell thalassemia beta plus without crisis
D57451Sickle-cell thalassemia beta plus with acute chest syndrome
D57452Sickle-cell thalassemia beta plus with splenic sequestration
D57453Sickle-cell thalassemia beta plus with cerebral vascular involvement
D57458Sickle-cell thalassemia beta plus with crisis with other specified complication
D57459Sickle-cell thalassemia beta plus with crisis, unspecified
D5780Other sickle-cell disorders without crisis
D57811Other sickle-cell disorders with acute chest syndrome
D57812Other sickle-cell disorders with splenic sequestration
D57813Other sickle-cell disorders with cerebral vascular involvement
D57818Other sickle-cell disorders with crisis with other specified complication
D57819Other sickle-cell disorders with crisis, unspecified
D580Hereditary spherocytosis
D581Hereditary elliptocytosis
D582Other hemoglobinopathies
D588Other specified hereditary hemolytic anemias
D589Hereditary hemolytic anemia, unspecified
D590Drug-induced autoimmune hemolytic anemia
D591Other autoimmune hemolytic anemias
D5910Autoimmune hemolytic anemia, unspecified
D5911Warm autoimmune hemolytic anemia
D5912Cold autoimmune hemolytic anemia
D5913Mixed type autoimmune hemolytic anemia
D5919Other autoimmune hemolytic anemia
D592Drug-induced nonautoimmune hemolytic anemia
D593Hemolytic-uremic syndrome
D5930Hemolytic-uremic syndrome, unspecified
D5931Infection-associated hemolytic-uremic syndrome
D5932Hereditary hemolytic-uremic syndrome
D5939Other hemolytic-uremic syndrome
D594Other nonautoimmune hemolytic anemias
D595Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
D596Hemoglobinuria due to hemolysis from other external causes
D598Other acquired hemolytic anemias
D599Acquired hemolytic anemia, unspecified

D60-D64 -Aplastic and Other Anemias and Bone Marrow Failure Syndromes:

This category includes conditions where the bone marrow fails to produce an adequate number of blood cells, including red blood cells, white blood cells, and platelets. Aplastic anemia is one of the primary conditions within this group.

ICD10 CodesDescription
D600Chronic acquired pure red cell aplasia
D601Transient acquired pure red cell aplasia
D608Other acquired pure red cell aplasias
D609Acquired pure red cell aplasia, unspecified
D6101Constitutional (pure) red blood cell aplasia
D6109Other constitutional aplastic anemia
D611Drug-induced aplastic anemia
D612Aplastic anemia due to other external agents
D613Idiopathic aplastic anemia
D61810Antineoplastic chemotherapy induced pancytopenia
D61811Other drug-induced pancytopenia
D61818Other pancytopenia
D6182Myelophthisis
D6189Other specified aplastic anemias and other bone marrow failure syndromes
D619Aplastic anemia, unspecified
D62Acute posthemorrhagic anemia
D630Anemia in neoplastic disease
D631Anemia in chronic kidney disease
D638Anemia in other chronic diseases classified elsewhere
D640Hereditary sideroblastic anemia
D641Secondary sideroblastic anemia due to disease
D642Secondary sideroblastic anemia due to drugs and toxins
D643Other sideroblastic anemias
D644Congenital dyserythropoietic anemia
D6481Anemia due to antineoplastic chemotherapy
D6489Other specified anemias
D649Anemia, unspecified

D65-D69 -Coagulation Defects, Purpura, and Other Hemorrhagic Conditions:

These codes encompass various bleeding disorders and conditions related to blood clotting. Examples include hemophilia (a hereditary bleeding disorder), von Willebrand disease (a clotting disorder), and purpura (a condition characterized by purple or red spots on the skin due to bleeding).

ICD 10 COdesDescription
D65Disseminated intravascular coagulation [defibrination syndrome]
D66Hereditary factor VIII deficiency
D67Hereditary factor IX deficiency
D68.0Von Willebrand’s disease
D68.00Von Willebrand disease, unspecified
D68.01Von Willebrand disease, type 1
D68.020Von Willebrand disease, type 2A
D68.021Von Willebrand disease, type 2B
D68.022Von Willebrand disease, type 2M
D68.023Von Willebrand disease, type 2N
D68.029Von Willebrand disease, type 2, unspecified
D68.03Von Willebrand disease, type 3
D68.04Acquired von Willebrand disease
D68.09Other von Willebrand disease
D68.1Hereditary factor XI deficiency
D68.2Hereditary deficiency of other clotting factors
D68.311Acquired hemophilia
D68.312Antiphospholipid antibody with hemorrhagic disorder
D68.318Other hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors
D68.32Hemorrhagic disorder due to extrinsic circulating anticoagulants
D68.4Acquired coagulation factor deficiency
D68.51Activated protein C resistance
D68.52Prothrombin gene mutation
D68.59Other primary thrombophilia
D68.61Antiphospholipid syndrome
D68.62Lupus anticoagulant syndrome
D68.69Other thrombophilia
D68.8Other specified coagulation defects
D68.9Coagulation defect, unspecified
D69.0Allergic purpura
D69.1Qualitative platelet defects
D69.2Other nonthrombocytopenic purpura
D69.3Immune thrombocytopenic purpura
D69.41Evans syndrome
D69.42Congenital and hereditary thrombocytopenia purpura
D69.49Other primary thrombocytopenia
D69.51Posttransfusion purpura
D69.59Other secondary thrombocytopenia
D69.6Thrombocytopenia, unspecified
D69.8Other specified hemorrhagic conditions
D69.9Hemorrhagic condition, unspecified

D70-D77 -Other Disorders of Blood and Blood-Forming Organs:

This category includes a wide range of blood disorders that don’t fit into the other categories listed. It covers conditions like eosinophilia (an increase in eosinophil white blood cells), leukopenia (a decrease in white blood cells), and polycythemia (an increase in red blood cells).

ICD10 CodesDescription
D700Congenital agranulocytosis
D701Agranulocytosis secondary to cancer chemotherapy
D702Other drug-induced agranulocytosis
D703Neutropenia due to infection
D704Cyclic neutropenia
D708Other neutropenia
D709Neutropenia, unspecified
D71Functional disorders of polymorphonuclear neutrophils
D720Genetic anomalies of leukocytes
D721Eosinophilia
D7210Eosinophilia, unspecified
D72110Idiopathic hypereosinophilic syndrome [IHES]
D72111Lymphocytic Variant Hypereosinophilic Syndrome [LHES]
D72118Other hypereosinophilic syndrome
D72119Hypereosinophilic syndrome [HES], unspecified
D7212Drug rash with eosinophilia and systemic symptoms syndrome
D7218Eosinophilia in diseases classified elsewhere
D7219Other eosinophilia
D72810Lymphocytopenia
D72818Other decreased white blood cell count
D72819Decreased white blood cell count, unspecified
D72820Lymphocytosis (symptomatic)
D72821Monocytosis (symptomatic)
D72822Plasmacytosis
D72823Leukemoid reaction
D72824Basophilia
D72825Bandemia
D72828Other elevated white blood cell count
D72829Elevated white blood cell count, unspecified
D7289Other specified disorders of white blood cells
D729Disorder of white blood cells, unspecified
D730Hyposplenism
D731Hypersplenism
D732Chronic congestive splenomegaly
D733Abscess of spleen
D734Cyst of spleen
D735Infarction of spleen
D7381Neutropenic splenomegaly
D7389Other diseases of spleen
D739Disease of spleen, unspecified
D740Congenital methemoglobinemia
D748Other methemoglobinemias
D749Methemoglobinemia, unspecified
D750Familial erythrocytosis
D751Secondary polycythemia
D7581Myelofibrosis
D7582Heparin induced thrombocytopenia (HIT)
D75821Non-immune heparin-induced thrombocytopenia
D75822Immune-mediated heparin-induced thrombocytopenia
D75828Other heparin-induced thrombocytopenia syndrome
D75829Heparin-induced thrombocytopenia, unspecified
D75838Other thrombocytosis
D75839Thrombocytosis, unspecified
D7584Other platelet-activating anti-PF4 disorders
D7589Other specified diseases of blood and blood-forming organs
D759Disease of blood and blood-forming organs, unspecified
D75AGlucose-6-phosphate dehydrgnse (G6PD) defic without anemia
D761Hemophagocytic lymphohistiocytosis
D762Hemophagocytic syndrome, infection-associated
D763Other histiocytosis syndromes
D77Other disorders of blood and blood-forming organs in diseases classified elsewhere

D78-D78 -Intraoperative and Postprocedural Complications of the Spleen:

This code specifically addresses complications related to surgical procedures involving the spleen. These complications can include bleeding, infection, or damage to the spleen during surgery.

ICD10 CodesDescription
D78.01Intraoperative hemorrhage and hematoma of the spleen complicating a procedure on the spleen
D78.02Intraoperative hemorrhage and hematoma of the spleen complicating other procedure
D78.11Accidental puncture and laceration of the spleen during a procedure on the spleen
D78.12Accidental puncture and laceration of the spleen during other procedure
D78.21Postprocedural hemorrhage of the spleen following a procedure on the spleen
D78.22Postprocedural hemorrhage of the spleen following other procedure
D78.31Postprocedural hematoma of the spleen following a procedure on the spleen
D78.32Postprocedural hematoma of the spleen following other procedure
D78.33Postprocedural seroma of the spleen following a procedure on the spleen
D78.34Postprocedural seroma of the spleen following other procedure
D78.81Other intraoperative complications of the spleen
D78.89Other postprocedural complications of the spleen

D80-D89 -Certain Disorders Involving the Immune Mechanism:

This category encompasses a variety of conditions that involve the immune system. It includes autoimmune disorders, immunodeficiency disorders (e.g., HIV/AIDS), and other immune-related conditions such as systemic lupus erythematosus (SLE) and rheumatoid arthritis.

ICD10 CodesDescription
D800Hereditary hypogammaglobulinemia
D801Nonfamilial hypogammaglobulinemia
D802Selective deficiency of immunoglobulin A [IgA]
D803Selective deficiency of immunoglobulin G [IgG] subclasses
D804Selective deficiency of immunoglobulin M [IgM]
D805Immunodeficiency with increased immunoglobulin M [IgM]
D806Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
D807Transient hypogammaglobulinemia of infancy
D808Other immunodeficiencies with predominantly antibody defects
D809Immunodeficiency with predominantly antibody defects, unspecified
D810Severe combined immunodeficiency [SCID] with reticular dysgenesis
D811Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
D812Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
D813Adenosine deaminase [ADA] deficiency
D814Nezelof’s syndrome
D815Purine nucleoside phosphorylase [PNP] deficiency
D816Major histocompatibility complex class I deficiency
D817Major histocompatibility complex class II deficiency
D81810Biotinidase deficiency
D81818Other biotin-dependent carboxylase deficiency
D81819Biotin-dependent carboxylase deficiency, unspecified
D8182Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]
D8189Other combined immunodeficiencies
D819Combined immunodeficiency, unspecified
D820Wiskott-Aldrich syndrome
D821Di George’s syndrome
D822Immunodeficiency with short-limbed stature
D823Immunodeficiency following hereditary defective response to Epstein-Barr virus
D824Hyperimmunoglobulin E [IgE] syndrome
D828Immunodeficiency associated with other specified major defects
D829Immunodeficiency associated with major defect, unspecified
D830Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
D831Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
D832Common variable immunodeficiency with autoantibodies to B- or T-cells
D838Other common variable immunodeficiencies
D839Common variable immunodeficiency, unspecified
D840Lymphocyte function antigen-1 [LFA-1] defect
D841Defects in the complement system
D848Other specified immunodeficiencies
D8481Immunodeficiency due to conditions classified elsewhere
D84821Immunodeficiency due to drugs
D84822Immunodeficiency due to external causes
D8489Other immunodeficiencies
D849Immunodeficiency, unspecified
D860Sarcoidosis of lung
D861Sarcoidosis of lymph nodes
D862Sarcoidosis of lung with sarcoidosis of lymph nodes
D863Sarcoidosis of skin
D8681Sarcoid meningitis
D8682Multiple cranial nerve palsies in sarcoidosis
D8683Sarcoid iridocyclitis
D8684Sarcoid pyelonephritis
D8685Sarcoid myocarditis
D8686Sarcoid arthropathy
D8687Sarcoid myositis
D8689Sarcoidosis of other sites
D869Sarcoidosis, unspecified
D890Polyclonal hypergammaglobulinemia
D891Cryoglobulinemia
D892Hypergammaglobulinemia, unspecified
D893Immune reconstitution syndrome
D8940Mast cell activation, unspecified
D8941Monoclonal mast cell activation syndrome
D8942Idiopathic mast cell activation syndrome
D8943Secondary mast cell activation
D8944Hereditary alpha tryptasemia
D8949Other mast cell activation disorder
D89810Acute graft-versus-host disease
D89811Chronic graft-versus-host disease
D89812Acute on chronic graft-versus-host disease
D89813Graft-versus-host disease, unspecified
D8982Autoimmune lymphoproliferative syndrome [ALPS]
D89831Cytokine release syndrome, grade 1
D89832Cytokine release syndrome, grade 2
D89833Cytokine release syndrome, grade 3
D89834Cytokine release syndrome, grade 4
D89835Cytokine release syndrome, grade 5
D89839Cytokine release syndrome, grade unspecified
D8989Other specified disorders involving the immune mechanism, not elsewhere classified
D89.9Disorder involving the immune mechanism, unspecified

In conclusion, “Diseases of the blood and blood-forming organs and certain disorders (D50-D89)” encompass a diverse group of medical conditions that affect the blood and its components and the organs responsible for blood production and regulation. These conditions vary widely regarding causes, symptoms, severity, and treatment options. Hematologists played a crucial role in diagnosing and managing these disorders, working to improve the quality of life for person affected by these conditions. Advances in medical research and treatment options continue to evolve, offering hope for better outcomes and improved management of these diseases. Understanding and addressing these disorders is vital for affected individuals’ overall health and well-being.

ICD Code RangePrincipal Diagnosis
A00B99Infectious/parasitic diseases
C00–D48Neoplasms
D50–D89Blood diseases
E00–E89Endocrine/metabolic diseases
F00–F99Mental/behavioral disorders
G00–G99Nervous system diseases
H00–H59Eye/adnexa diseases
H60–H95Ear/mastoid diseases
I00–I99Circulatory system diseases
J00–J99Respiratory system diseases
K00–K93Digestive system diseases
L00–L99Skin diseases
M00–M99Musculoskeletal system diseases
N00–N99Genitourinary system diseases
O00–O99Pregnancy/childbirth
P00–P96Certain conditions originating in the perinatal period
Q00–Q99Congenital malformations
R00–R99Conditions not elsewhere classified
S00–T98Injury, poisoning, external causes
V01–Y98External causes of morbidity and mortality
Z00–Z99Factors influencing health status and contact with health services
U00–U99Codes for special purposes

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