“Diseases of the blood and blood-forming organs and certain disorders” is a broad medical category (D50-D89) encompassing a range of conditions that affect the blood and its components and disorders related to the organs responsible for blood production and regulation. This category includes various hematological disorders and conditions, such as:
- Anemia is characterized by a decrease in the number of red blood cells or a decrease in the amount of hemoglobin in the blood. It can result from various causes, including iron deficiency, vitamin deficiencies, chronic diseases, or genetic factors.
- Hemophilia: Hemophilia is a genetic disorder that impairs the blood’s ability to clot properly, leading to prolonged bleeding and easy bruising.
- Leukemia: Leukemia is a type of cancer that affects the bone marrow and blood, causing an abnormal increase in white blood cells. There are different types of leukemia, including acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic myeloid leukemia (CML).
- Thrombocytopenia: Thrombocytopenia is a condition characterized by a low platelet count in the blood, which can lead to an increased risk of bleeding and bruising.
- Sickle Cell Disease: Sickle cell disease is a genetic disorder that affects the shape of red blood cells, causing them to become rigid and assume a “sickle” shape. This can lead to pain, anemia, and other complications.
- Polycythemia: Polycythemia is a condition in which there is an excessive production of red blood cells, leading to an increased blood volume and viscosity.
- Myelodysplastic Syndromes (MDS) refers to bone marrow disorders characterized by abnormal blood cell production. It can progress to acute leukemia in some cases.
- Hemochromatosis: Hemochromatosis is a genetic disorder that causes the body to absorb and store too much iron, which can lead to organ damage over time.
- Idiopathic Thrombocytopenic Purpura (ITP): ITP is an autoimmune disorder in which the immune system mistakenly destroys platelets, leading to a low platelet count and an increased risk of bleeding.
- Coagulation disorders affect the blood’s ability to clot properly and can lead to bleeding disorders (hemorrhagic) or clotting disorders (thrombotic), such as von Willebrand disease or deep vein thrombosis.
- Bone Marrow Disorders: Various conditions can affect the bone marrow, where blood cells are produced, including aplastic anemia, myelofibrosis, and others.
These are just a few examples of the many diseases and disorders that fall under the “Diseases of the blood and blood-forming organs and certain disorders.” Each condition has its causes, symptoms, diagnostic methods, and treatment approaches, and they are typically managed by hematologists medical specialists who focus on blood-related disorders.
D50-D53 Nutritional Anemias:
These codes represent a group of anemias that result from various nutritional deficiencies. The most common forms include:
- D50 Iron-deficiency anemia: Often caused by a lack of dietary iron or poor absorption of iron by the body. It results in a reduced ability of the blood to carry oxygen.
- D51 Vitamin B12-deficiency anemia: Typically caused by inadequate intake or absorption of vitamin B12, which is essential for red blood cell production.
- D52 Folate-deficiency anemia: Results from insufficient dietary intake or absorption of folate (vitamin B9), which is necessary for proper red blood cell formation.
- D53 Other nutritional anemias: Encompasses anemias arising from various nutritional deficiencies other than iron, vitamin B12, or folate.
ICD10 Codes | Description |
---|---|
D50.0 | Iron deficiency anemia secondary to blood loss (chronic) |
D50.1 | Sideropenic dysphagia |
D50.8 | Other iron deficiency anemias |
D50.9 | Iron deficiency anemia, unspecified |
D51.0 | Vitamin B12 deficiency anemia due to intrinsic factor deficiency |
D51.1 | Vitamin B12 deficiency anemia due to selective vitamin B12 malabsorption with proteinuria |
D51.2 | Transcobalamin II deficiency |
D51.3 | Other dietary vitamin B12 deficiency anemia |
D51.8 | Other vitamin B12 deficiency anemias |
D51.9 | Vitamin B12 deficiency anemia, unspecified |
D52.0 | Dietary folate deficiency anemia |
D52.1 | Drug-induced folate deficiency anemia |
D52.8 | Other folate deficiency anemias |
D52.9 | Folate deficiency anemia, unspecified |
D53.0 | Protein deficiency anemia |
D53.1 | Other megaloblastic anemias, not elsewhere classified |
D53.2 | Scorbutic anemia |
D53.8 | Other specified nutritional anemias |
D53.9 | Nutritional anemia, unspecified |
D55-D59 -Hemolytic Anemias:
These codes cover a group of anemias characterized by the destruction of red blood cells (hemolysis) either within the bloodstream or in the spleen. Hemolytic anemias can be inherited (e.g., sickle cell anemia) or acquired (e.g., autoimmune hemolytic anemia).
ICD 10 Codes | Description |
---|---|
D550 | Anemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency |
D551 | Anemia due to other disorders of glutathione metabolism |
D552 | Anemia due to disorders of glycolytic enzymes |
D5521 | Anemia due to pyruvate kinase deficiency |
D5529 | Anemia due to other disorders of glycolytic enzymes |
D553 | Anemia due to disorders of nucleotide metabolism |
D558 | Other anemias due to enzyme disorders |
D559 | Anemia due to enzyme disorder, unspecified |
D560 | Alpha thalassemia |
D561 | Beta thalassemia |
D562 | Delta-beta thalassemia |
D563 | Thalassemia minor |
D564 | Hereditary persistence of fetal hemoglobin [HPFH] |
D565 | Hemoglobin E-beta thalassemia |
D568 | Other thalassemias |
D569 | Thalassemia, unspecified |
D5700 | Hb-SS disease with crisis, unspecified |
D5701 | Hb-SS disease with acute chest syndrome |
D5702 | Hb-SS disease with splenic sequestration |
D5703 | Hb-SS disease with cerebral vascular involvement |
D5709 | Hb-SS disease with crisis with other specified complication |
D571 | Sickle-cell disease without crisis |
D5720 | Sickle-cell/Hb-C disease without crisis |
D57211 | Sickle-cell/Hb-C disease with acute chest syndrome |
D57212 | Sickle-cell/Hb-C disease with splenic sequestration |
D57213 | Sickle-cell/Hb-C disease with cerebral vascular involvement |
D57218 | Sickle-cell/Hb-C disease with crisis with other specified complication |
D57219 | Sickle-cell/Hb-C disease with crisis, unspecified |
D573 | Sickle-cell trait |
D5740 | Sickle-cell thalassemia without crisis |
D5741 | Sickle-cell thalassemia, unspecified, with crisis |
D57411 | Sickle-cell thalassemia, unspecified, with acute chest syndrome |
D57412 | Sickle-cell thalassemia, unspecified, with splenic sequestration |
D57413 | Sickle-cell thalassemia, unspecified, with cerebral vascular involvement |
D57418 | Sickle-cell thalassemia, unspecified, with crisis with other specified complication |
D57419 | Sickle-cell thalassemia, unspecified, with crisis |
D5742 | Sickle-cell thalassemia beta zero without crisis |
D57431 | Sickle-cell thalassemia beta zero with acute chest syndrome |
D57432 | Sickle-cell thalassemia beta zero with splenic sequestration |
D57433 | Sickle-cell thalassemia beta zero with cerebral vascular involvement |
D57438 | Sickle-cell thalassemia beta zero with crisis with other specified complication |
D57439 | Sickle-cell thalassemia beta zero with crisis, unspecified |
D5744 | Sickle-cell thalassemia beta plus without crisis |
D57451 | Sickle-cell thalassemia beta plus with acute chest syndrome |
D57452 | Sickle-cell thalassemia beta plus with splenic sequestration |
D57453 | Sickle-cell thalassemia beta plus with cerebral vascular involvement |
D57458 | Sickle-cell thalassemia beta plus with crisis with other specified complication |
D57459 | Sickle-cell thalassemia beta plus with crisis, unspecified |
D5780 | Other sickle-cell disorders without crisis |
D57811 | Other sickle-cell disorders with acute chest syndrome |
D57812 | Other sickle-cell disorders with splenic sequestration |
D57813 | Other sickle-cell disorders with cerebral vascular involvement |
D57818 | Other sickle-cell disorders with crisis with other specified complication |
D57819 | Other sickle-cell disorders with crisis, unspecified |
D580 | Hereditary spherocytosis |
D581 | Hereditary elliptocytosis |
D582 | Other hemoglobinopathies |
D588 | Other specified hereditary hemolytic anemias |
D589 | Hereditary hemolytic anemia, unspecified |
D590 | Drug-induced autoimmune hemolytic anemia |
D591 | Other autoimmune hemolytic anemias |
D5910 | Autoimmune hemolytic anemia, unspecified |
D5911 | Warm autoimmune hemolytic anemia |
D5912 | Cold autoimmune hemolytic anemia |
D5913 | Mixed type autoimmune hemolytic anemia |
D5919 | Other autoimmune hemolytic anemia |
D592 | Drug-induced nonautoimmune hemolytic anemia |
D593 | Hemolytic-uremic syndrome |
D5930 | Hemolytic-uremic syndrome, unspecified |
D5931 | Infection-associated hemolytic-uremic syndrome |
D5932 | Hereditary hemolytic-uremic syndrome |
D5939 | Other hemolytic-uremic syndrome |
D594 | Other nonautoimmune hemolytic anemias |
D595 | Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli] |
D596 | Hemoglobinuria due to hemolysis from other external causes |
D598 | Other acquired hemolytic anemias |
D599 | Acquired hemolytic anemia, unspecified |
D60-D64 -Aplastic and Other Anemias and Bone Marrow Failure Syndromes:
This category includes conditions where the bone marrow fails to produce an adequate number of blood cells, including red blood cells, white blood cells, and platelets. Aplastic anemia is one of the primary conditions within this group.
ICD10 Codes | Description |
---|---|
D600 | Chronic acquired pure red cell aplasia |
D601 | Transient acquired pure red cell aplasia |
D608 | Other acquired pure red cell aplasias |
D609 | Acquired pure red cell aplasia, unspecified |
D6101 | Constitutional (pure) red blood cell aplasia |
D6109 | Other constitutional aplastic anemia |
D611 | Drug-induced aplastic anemia |
D612 | Aplastic anemia due to other external agents |
D613 | Idiopathic aplastic anemia |
D61810 | Antineoplastic chemotherapy induced pancytopenia |
D61811 | Other drug-induced pancytopenia |
D61818 | Other pancytopenia |
D6182 | Myelophthisis |
D6189 | Other specified aplastic anemias and other bone marrow failure syndromes |
D619 | Aplastic anemia, unspecified |
D62 | Acute posthemorrhagic anemia |
D630 | Anemia in neoplastic disease |
D631 | Anemia in chronic kidney disease |
D638 | Anemia in other chronic diseases classified elsewhere |
D640 | Hereditary sideroblastic anemia |
D641 | Secondary sideroblastic anemia due to disease |
D642 | Secondary sideroblastic anemia due to drugs and toxins |
D643 | Other sideroblastic anemias |
D644 | Congenital dyserythropoietic anemia |
D6481 | Anemia due to antineoplastic chemotherapy |
D6489 | Other specified anemias |
D649 | Anemia, unspecified |
D65-D69 -Coagulation Defects, Purpura, and Other Hemorrhagic Conditions:
These codes encompass various bleeding disorders and conditions related to blood clotting. Examples include hemophilia (a hereditary bleeding disorder), von Willebrand disease (a clotting disorder), and purpura (a condition characterized by purple or red spots on the skin due to bleeding).
ICD 10 COdes | Description |
---|---|
D65 | Disseminated intravascular coagulation [defibrination syndrome] |
D66 | Hereditary factor VIII deficiency |
D67 | Hereditary factor IX deficiency |
D68.0 | Von Willebrand’s disease |
D68.00 | Von Willebrand disease, unspecified |
D68.01 | Von Willebrand disease, type 1 |
D68.020 | Von Willebrand disease, type 2A |
D68.021 | Von Willebrand disease, type 2B |
D68.022 | Von Willebrand disease, type 2M |
D68.023 | Von Willebrand disease, type 2N |
D68.029 | Von Willebrand disease, type 2, unspecified |
D68.03 | Von Willebrand disease, type 3 |
D68.04 | Acquired von Willebrand disease |
D68.09 | Other von Willebrand disease |
D68.1 | Hereditary factor XI deficiency |
D68.2 | Hereditary deficiency of other clotting factors |
D68.311 | Acquired hemophilia |
D68.312 | Antiphospholipid antibody with hemorrhagic disorder |
D68.318 | Other hemorrhagic disorder due to intrinsic circulating anticoagulants, antibodies, or inhibitors |
D68.32 | Hemorrhagic disorder due to extrinsic circulating anticoagulants |
D68.4 | Acquired coagulation factor deficiency |
D68.51 | Activated protein C resistance |
D68.52 | Prothrombin gene mutation |
D68.59 | Other primary thrombophilia |
D68.61 | Antiphospholipid syndrome |
D68.62 | Lupus anticoagulant syndrome |
D68.69 | Other thrombophilia |
D68.8 | Other specified coagulation defects |
D68.9 | Coagulation defect, unspecified |
D69.0 | Allergic purpura |
D69.1 | Qualitative platelet defects |
D69.2 | Other nonthrombocytopenic purpura |
D69.3 | Immune thrombocytopenic purpura |
D69.41 | Evans syndrome |
D69.42 | Congenital and hereditary thrombocytopenia purpura |
D69.49 | Other primary thrombocytopenia |
D69.51 | Posttransfusion purpura |
D69.59 | Other secondary thrombocytopenia |
D69.6 | Thrombocytopenia, unspecified |
D69.8 | Other specified hemorrhagic conditions |
D69.9 | Hemorrhagic condition, unspecified |
D70-D77 -Other Disorders of Blood and Blood-Forming Organs:
This category includes a wide range of blood disorders that don’t fit into the other categories listed. It covers conditions like eosinophilia (an increase in eosinophil white blood cells), leukopenia (a decrease in white blood cells), and polycythemia (an increase in red blood cells).
ICD10 Codes | Description |
---|---|
D700 | Congenital agranulocytosis |
D701 | Agranulocytosis secondary to cancer chemotherapy |
D702 | Other drug-induced agranulocytosis |
D703 | Neutropenia due to infection |
D704 | Cyclic neutropenia |
D708 | Other neutropenia |
D709 | Neutropenia, unspecified |
D71 | Functional disorders of polymorphonuclear neutrophils |
D720 | Genetic anomalies of leukocytes |
D721 | Eosinophilia |
D7210 | Eosinophilia, unspecified |
D72110 | Idiopathic hypereosinophilic syndrome [IHES] |
D72111 | Lymphocytic Variant Hypereosinophilic Syndrome [LHES] |
D72118 | Other hypereosinophilic syndrome |
D72119 | Hypereosinophilic syndrome [HES], unspecified |
D7212 | Drug rash with eosinophilia and systemic symptoms syndrome |
D7218 | Eosinophilia in diseases classified elsewhere |
D7219 | Other eosinophilia |
D72810 | Lymphocytopenia |
D72818 | Other decreased white blood cell count |
D72819 | Decreased white blood cell count, unspecified |
D72820 | Lymphocytosis (symptomatic) |
D72821 | Monocytosis (symptomatic) |
D72822 | Plasmacytosis |
D72823 | Leukemoid reaction |
D72824 | Basophilia |
D72825 | Bandemia |
D72828 | Other elevated white blood cell count |
D72829 | Elevated white blood cell count, unspecified |
D7289 | Other specified disorders of white blood cells |
D729 | Disorder of white blood cells, unspecified |
D730 | Hyposplenism |
D731 | Hypersplenism |
D732 | Chronic congestive splenomegaly |
D733 | Abscess of spleen |
D734 | Cyst of spleen |
D735 | Infarction of spleen |
D7381 | Neutropenic splenomegaly |
D7389 | Other diseases of spleen |
D739 | Disease of spleen, unspecified |
D740 | Congenital methemoglobinemia |
D748 | Other methemoglobinemias |
D749 | Methemoglobinemia, unspecified |
D750 | Familial erythrocytosis |
D751 | Secondary polycythemia |
D7581 | Myelofibrosis |
D7582 | Heparin induced thrombocytopenia (HIT) |
D75821 | Non-immune heparin-induced thrombocytopenia |
D75822 | Immune-mediated heparin-induced thrombocytopenia |
D75828 | Other heparin-induced thrombocytopenia syndrome |
D75829 | Heparin-induced thrombocytopenia, unspecified |
D75838 | Other thrombocytosis |
D75839 | Thrombocytosis, unspecified |
D7584 | Other platelet-activating anti-PF4 disorders |
D7589 | Other specified diseases of blood and blood-forming organs |
D759 | Disease of blood and blood-forming organs, unspecified |
D75A | Glucose-6-phosphate dehydrgnse (G6PD) defic without anemia |
D761 | Hemophagocytic lymphohistiocytosis |
D762 | Hemophagocytic syndrome, infection-associated |
D763 | Other histiocytosis syndromes |
D77 | Other disorders of blood and blood-forming organs in diseases classified elsewhere |
D78-D78 -Intraoperative and Postprocedural Complications of the Spleen:
This code specifically addresses complications related to surgical procedures involving the spleen. These complications can include bleeding, infection, or damage to the spleen during surgery.
ICD10 Codes | Description |
---|---|
D78.01 | Intraoperative hemorrhage and hematoma of the spleen complicating a procedure on the spleen |
D78.02 | Intraoperative hemorrhage and hematoma of the spleen complicating other procedure |
D78.11 | Accidental puncture and laceration of the spleen during a procedure on the spleen |
D78.12 | Accidental puncture and laceration of the spleen during other procedure |
D78.21 | Postprocedural hemorrhage of the spleen following a procedure on the spleen |
D78.22 | Postprocedural hemorrhage of the spleen following other procedure |
D78.31 | Postprocedural hematoma of the spleen following a procedure on the spleen |
D78.32 | Postprocedural hematoma of the spleen following other procedure |
D78.33 | Postprocedural seroma of the spleen following a procedure on the spleen |
D78.34 | Postprocedural seroma of the spleen following other procedure |
D78.81 | Other intraoperative complications of the spleen |
D78.89 | Other postprocedural complications of the spleen |
D80-D89 -Certain Disorders Involving the Immune Mechanism:
This category encompasses a variety of conditions that involve the immune system. It includes autoimmune disorders, immunodeficiency disorders (e.g., HIV/AIDS), and other immune-related conditions such as systemic lupus erythematosus (SLE) and rheumatoid arthritis.
ICD10 Codes | Description |
---|---|
D800 | Hereditary hypogammaglobulinemia |
D801 | Nonfamilial hypogammaglobulinemia |
D802 | Selective deficiency of immunoglobulin A [IgA] |
D803 | Selective deficiency of immunoglobulin G [IgG] subclasses |
D804 | Selective deficiency of immunoglobulin M [IgM] |
D805 | Immunodeficiency with increased immunoglobulin M [IgM] |
D806 | Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia |
D807 | Transient hypogammaglobulinemia of infancy |
D808 | Other immunodeficiencies with predominantly antibody defects |
D809 | Immunodeficiency with predominantly antibody defects, unspecified |
D810 | Severe combined immunodeficiency [SCID] with reticular dysgenesis |
D811 | Severe combined immunodeficiency [SCID] with low T- and B-cell numbers |
D812 | Severe combined immunodeficiency [SCID] with low or normal B-cell numbers |
D813 | Adenosine deaminase [ADA] deficiency |
D814 | Nezelof’s syndrome |
D815 | Purine nucleoside phosphorylase [PNP] deficiency |
D816 | Major histocompatibility complex class I deficiency |
D817 | Major histocompatibility complex class II deficiency |
D81810 | Biotinidase deficiency |
D81818 | Other biotin-dependent carboxylase deficiency |
D81819 | Biotin-dependent carboxylase deficiency, unspecified |
D8182 | Activated Phosphoinositide 3-kinase Delta Syndrome [APDS] |
D8189 | Other combined immunodeficiencies |
D819 | Combined immunodeficiency, unspecified |
D820 | Wiskott-Aldrich syndrome |
D821 | Di George’s syndrome |
D822 | Immunodeficiency with short-limbed stature |
D823 | Immunodeficiency following hereditary defective response to Epstein-Barr virus |
D824 | Hyperimmunoglobulin E [IgE] syndrome |
D828 | Immunodeficiency associated with other specified major defects |
D829 | Immunodeficiency associated with major defect, unspecified |
D830 | Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function |
D831 | Common variable immunodeficiency with predominant immunoregulatory T-cell disorders |
D832 | Common variable immunodeficiency with autoantibodies to B- or T-cells |
D838 | Other common variable immunodeficiencies |
D839 | Common variable immunodeficiency, unspecified |
D840 | Lymphocyte function antigen-1 [LFA-1] defect |
D841 | Defects in the complement system |
D848 | Other specified immunodeficiencies |
D8481 | Immunodeficiency due to conditions classified elsewhere |
D84821 | Immunodeficiency due to drugs |
D84822 | Immunodeficiency due to external causes |
D8489 | Other immunodeficiencies |
D849 | Immunodeficiency, unspecified |
D860 | Sarcoidosis of lung |
D861 | Sarcoidosis of lymph nodes |
D862 | Sarcoidosis of lung with sarcoidosis of lymph nodes |
D863 | Sarcoidosis of skin |
D8681 | Sarcoid meningitis |
D8682 | Multiple cranial nerve palsies in sarcoidosis |
D8683 | Sarcoid iridocyclitis |
D8684 | Sarcoid pyelonephritis |
D8685 | Sarcoid myocarditis |
D8686 | Sarcoid arthropathy |
D8687 | Sarcoid myositis |
D8689 | Sarcoidosis of other sites |
D869 | Sarcoidosis, unspecified |
D890 | Polyclonal hypergammaglobulinemia |
D891 | Cryoglobulinemia |
D892 | Hypergammaglobulinemia, unspecified |
D893 | Immune reconstitution syndrome |
D8940 | Mast cell activation, unspecified |
D8941 | Monoclonal mast cell activation syndrome |
D8942 | Idiopathic mast cell activation syndrome |
D8943 | Secondary mast cell activation |
D8944 | Hereditary alpha tryptasemia |
D8949 | Other mast cell activation disorder |
D89810 | Acute graft-versus-host disease |
D89811 | Chronic graft-versus-host disease |
D89812 | Acute on chronic graft-versus-host disease |
D89813 | Graft-versus-host disease, unspecified |
D8982 | Autoimmune lymphoproliferative syndrome [ALPS] |
D89831 | Cytokine release syndrome, grade 1 |
D89832 | Cytokine release syndrome, grade 2 |
D89833 | Cytokine release syndrome, grade 3 |
D89834 | Cytokine release syndrome, grade 4 |
D89835 | Cytokine release syndrome, grade 5 |
D89839 | Cytokine release syndrome, grade unspecified |
D8989 | Other specified disorders involving the immune mechanism, not elsewhere classified |
D89.9 | Disorder involving the immune mechanism, unspecified |
In conclusion, “Diseases of the blood and blood-forming organs and certain disorders (D50-D89)” encompass a diverse group of medical conditions that affect the blood and its components and the organs responsible for blood production and regulation. These conditions vary widely regarding causes, symptoms, severity, and treatment options. Hematologists played a crucial role in diagnosing and managing these disorders, working to improve the quality of life for person affected by these conditions. Advances in medical research and treatment options continue to evolve, offering hope for better outcomes and improved management of these diseases. Understanding and addressing these disorders is vital for affected individuals’ overall health and well-being.
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ICD Code Range | Principal Diagnosis |
A00–B99 | Infectious/parasitic diseases |
C00–D48 | Neoplasms |
D50–D89 | Blood diseases |
E00–E89 | Endocrine/metabolic diseases |
F00–F99 | Mental/behavioral disorders |
G00–G99 | Nervous system diseases |
H00–H59 | Eye/adnexa diseases |
H60–H95 | Ear/mastoid diseases |
I00–I99 | Circulatory system diseases |
J00–J99 | Respiratory system diseases |
K00–K93 | Digestive system diseases |
L00–L99 | Skin diseases |
M00–M99 | Musculoskeletal system diseases |
N00–N99 | Genitourinary system diseases |
O00–O99 | Pregnancy/childbirth |
P00–P96 | Certain conditions originating in the perinatal period |
Q00–Q99 | Congenital malformations |
R00–R99 | Conditions not elsewhere classified |
S00–T98 | Injury, poisoning, external causes |
V01–Y98 | External causes of morbidity and mortality |
Z00–Z99 | Factors influencing health status and contact with health services |
U00–U99 | Codes for special purposes |
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